Dept of Ob/Gyn and Reproductive Sciences
Glycobiology Research and Training Center
UC San Diego
X-ray tomograph of fetoplacental units inside the uterine horn from a pregnant mouse.
Thanks to James Fitzpatrick and team at the Washington University Center for Cellular Imaging
Mouse model of infection in pregnancy shows
Gardnerella encourages invasive GBS disease
Gilbert, NM Foster LR, Cao B, Yin Y, Mysorekar IU, Lewis AL. Gardnerella vaginalis promotes group B Streptococcus vaginal colonization, enabling ascending uteroplacental infection in pregnant mice. Am J Obstet Gynecol, 2020 Nov 25, S0002-9378(20)31331-4. doi:10.1016/j.ajog.2020.11.032 PMID: 33248136
Co-inoculation with Gardnerella results in increased GBS invasive ascending infection. Left: Schematic of the basic experimental design.
(A-B) Number of dams without or with bacterial cfu in uterine horn (A) or placental (B) tissue homogenates. Percentage of dams with detectable cfu indicated across the top of each bar. Fisher’s exact test *P < 0.05; np = not powered.