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  Amanda Lewis, Ph.D.

 Bacteria, Glycobiology, and Women's Health



Department of Ob/Gyn and Reproductive Sciences

Division of Maternal-Fetal Medicine

Co-Director, Glycobiology Research and Training Center

Director, UC Glycosciences Consortium for Women's Health

University of California San Diego

Contact me: e-mail: a1lewis[at]

The composition of bacteria in the human vagina has been linked to health and disease. Our lab builds experimental models to understand how vaginal bacteria interact with each other and the host and how these events lead to colonization and pathophysiology

The Vaginal Microbiome

Gardnerella interacting with a mouse epithelial cell

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Human vaginal epithelial cell with intact, fuzzy layer of glycans (left) or damaged surface glycans (right) in bacterial vaginosis

(Sci. Transl. Med. 2023)

Glycans and the microbiome in health and disease

 Carbohydrates (glycans) are rich at mucosal surfaces and are involved in many host-microbe interactions. We investigate glycans in health and disease with an emphasis on the female genitourinary systems

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